Saturday, December 08, 2018 8:56:50 PM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160973/
Overall, multiple clinical trials have demonstrated an excellent safety profile with attenuated Lm vaccines in humans.
One such strategy has been to directly target angiogenesis using Lm vaccines. Indeed, Lm vaccines targeting tumor-associated angiogenic proteins, including CD105 and VEGFR2, have demonstrated inhibited tumor growth [97,98,99,100] as well as the ability to induce secondary antitumor immune responses via epitope spreading [98,99].
....Other studies are likely to explore combination approaches using Lm vaccines with radiation, chemotherapy, immune checkpoint inhibitors, and other drugs. These studies are expected to firmly establish the utility of Lm vaccines in the emerging immunotherapeutic landscape for the benefit of patients with a variety of malignancies.
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