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Friday, December 07, 2018 9:03:30 PM
https://edition.cnn.com/2018/12/05/health/10-minute-cancer-test-intl/index.html
The 10-minute test developed in Australia is yet to be used on humans, and large clinical trials are needed before it can be used on prospective patients. But the signs are positive.
Tests on more than 200 tissue and blood samples detected cancerous cells with 90% accuracy, the researchers said.
It's been used only to detect breast, prostate, bowel and lymphoma cancers, but they're confident the results can be replicated with other types of the disease. Exsosomes what could have been.
Breast cancer: Know the facts 01:19
"Researchers have long been looking for a commonality among cancers to develop a diagnostic tool that could apply across all types," wrote Trau and his research partners, Sina and Laura Carrascosa, in an article for academic news site The Conversation.
Cancer alters the DNA of healthy cells, particularly in the distribution of molecules known as methyl groups, and the test detects this altered patterning when placed in a solution such as water.
"Using ... a high-resolution microscope, we saw that cancerous DNA fragments folded into three-dimensional structures in water. These were different to what we saw with normal tissue DNA in the water," the article explains.
The test uses gold particles, which bind with cancer-affected DNA and "can affect molecular behavior in a way that causes visible color changes," it added.
Carrascosa says that if proved, their method for detecting cancer could be a boon to providing detection and diagnosis in rural or underdeveloped areas. The technology for reading electrochemical signals is readily available, she says, and paired with a smartphone could be adapted to screen DNA affected by cancer.
"The advantage of this method, it is so simple -- it's almost equipment-free. You can do it with very low resources.
"There's another possibility that it can be used to monitor for relapses. We haven't tested that yet, but it is a potential."
The next step for the team is to stage clinical studies into how early cancer can be detected,and whether the test can be used to gauge the effectiveness of treatment.
They're also looking into the possibility of using different bodily fluids to detect different cancer types from early to the later stages of the disease.
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