PreveCeutical Doubles Contents of Fingerprinted Cannabis Extract Library
November 20, 2018, Vancouver, British Columbia: PreveCeuticalMedical Inc. (the “Company” or “PreveCeutical”)(CSE: PREV, OTCQB: PRVCF, FSE: 18H), announces that it has developed an optimized protocol to convert phytocannabinoids extracted from the Company’s five cannabis strains from their acid forms to their neutral forms (the “Neutralization Protocol”).
Specifically, the Company’s Neutralization Protocol has confirmed the comprehensive conversion of cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA) to their neutral forms, canabidiol (CBD) and tetrahydrocannabinol (THC), respectively, without generating any detectable degradative products in the process. Further, the Neutralization Protocol has been verified via High-Performance Liquid Chromatography (HPLC) analysis using commercial cannabinoid standards.
The successful conversion of phytocannabinoids from their acid to neutral forms is an important development from a clinical perspective, as reports continue to emerge highlighting the benefits of using both acid and neutral forms of cannabinoids in treating a range of diseases and ailments.
As a result of the Neutralization Protocol, PreveCeutical has now doubled the number of extracts in its fingerprinted cannabis extract library by adding the five neutral form cannabinoid extracts to the five acid form cannabinoid extracts which were entered into the library earlier in 2018. For further information on the fingerprinted cannabis extract library (see news releases dated September 4, 2018, and November 5, 2018).
Next, the Company intends to pursue independent incorporation of both the acid and neutral form extracts into its soluble gel drug delivery program (the “Sol-gel Program”) to generate a range of cannabinoid-based soluble gel formulations (each, a “CBD Sol-gel Formulation”), complemented by the Company’s custom soluble gel applicator device (the “Sol-gel Applicator”) for nose-to-brain drug delivery.
The Company’s Chief Research Officer, Dr. Harendra Parekh stated, “Having optimized the conditions for comprehensive conversion of phytocannabinoids from acid to neutral forms opens the door to a wider product range for PreveCeutical, which is aimed at meeting the ever-increasing demands by physicians and patients alike, for chemically-validated, dose-standardized products.”
The CBD Sol-gel Formulations, when used with the Company’s Sol-gel Applicator, will facilitate prolonged delivery of cannabinoids to patients’ central nervous systems. The Company’s medicinal cannabis division expects to be able to offer a broad product range that can be tailored to specific medical conditions. For example, the Company is currently developing a CBD Sol-gel Formulation with a cannabinoid composition designed to treat patient anxiety (see news release dated August 8, 2018).
PreveCeutical’sSol-gel Applicator is currently in development. The Company’s research partner, the University of Queensland, has received several prototypes for the Sol-gel Applicator from the Company’s manufacturer, and has been assessing their performance in the Sol-gel Program.
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