Innovation Pharmaceuticals Inc (IPIX)

[loanranger]

Does anyone understand the B-UP poster well enough to explain the Retention Time table?

If I'm reading it right....
Cohort A shows 5 out of 6 subjects with RTs of over 4hrs.
Cohort B shows 4 out of 6 subjects with RTs of 30min to 1hr.
Cohort C shows 3 out of 5 subjects with RTs of over 4hrs.

It's my understanding that each enema in all cohorts had a volume of 60ml with the only variation between the enemas being A included 50mg of Brilacidin, B with 100mg and C with 200mg. So the total volumes didn't vary...all subjects got the same physical amounts of material per enema.

1. Why would retention times vary at all given the consistent volumes?
2. What would have caused the grouping of retention times, especially at DIFFERENT times?

The heading to the table reads "Overall good retention times for a water based enema".
The typical retention enema is intended to be retained overnight. And I believe that retention failures are typically due to the severity of the disease in the individual and not due to a given characteristic of the material in the enema. Am I wrong about that?

Generally people with Active Mild-to-Moderate Ulcerative Proctitis (UP)/Ulcerative Proctosigmoiditis (UPS) aren't hospitalized for treatment. Would they have been hospitalized for the trial? If not, wouldn't that present a control issue?

https://static1.squarespace.com/static/5715352e20c647639137f992/t/5beac1250ebbe846eb4b031e/1542111528589/IPI+IBD+Innovate+2018+Poster+%28final%29.pdf

The results appear to be pretty remarkable.