Biotech Values

[dewophile]

The thing with TKIs is that they tend to be cytostatic rather than cytotoxic

I think most people now believe there is cell killing with TKIs too. When you disrupt the mutation driving the cancer apoptosis may kick in.
even without the cell killing causing release of neoantigens TKIs are so effective when there is large tumor burden that they can potentially be used to debulk the tumors initially before checkpoints. I've read that this is often the case when deciding between a TKI and PD-1 for BRAF mutated melanoma for example if you don't think the patient can wait for the checkpoint to start working