PARPi would fall into my proven drug category. Still, it is theoretical not proven in clinic. Data from several PARPi in combination with anti-PD1 had been presented, it is mixed but interesting nevertheless. It wasn’t as apparent as anti-PD1 in combination with chemo/TKI based on earlier data. It might take time to work or find right indications and settings etc, but definitely worth of exploring further. MRK deal with AZN on PARPi probably was a lower risk bet on PARPi beyond monotherapy alone.
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