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Re: rfj1862 post# 222132

Saturday, 11/10/2018 5:45:12 PM

Saturday, November 10, 2018 5:45:12 PM

Post# of 252412
BTW: Technically, tertiary endpoints can’t be considered statsig unless all secondary endpoints have been met (in hierarchical order). Since REDUCE-IT’s lowest-ranking secondary endpoint—all-cause mortality—was not statsig (a close miss), there is no alpha for any of the tertiary endpoints.

The chart in #msg-144802758 shows the REDUCE-IT secondary endpoints in hierarchical order.

The above is a general nitpick; it doesn't change anything we said earlier in this thread.

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