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jondoeuk

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jondoeuk

Re: Murph1953 post# 60

Tuesday, 11/06/2018 6:09:41 PM

Tuesday, November 06, 2018 6:09:41 PM

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It should activate the pathway in multiple cells in the TME (including macrophages and ECs to name of few). The innate response is via neutrophils after TNFa has caused hemorrhagic necrosis. Adaptive response is dependent on STING and IFNB activation in DCs. Abscopal effects through polyfunctional antigen specific T-cells.
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