LadRx Corp (LADXD)

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CYTR~~ Key Emerging Oncology Trends By Big Pharma Strengthen CytRx's Rationally Designed, Targeted Therapies Pipeline

PR Newswire

October 31, 2018

Aldoxorubicin Being Studied in NantCell Clinical Trials in Combination with Immune-Based Therapy for the Treatment of Squamous Cell Carcinoma, Metastatic Pancreatic and Triple Negative Breast Cancers

Breakthrough LADR™ Drug Candidates Have the Potential to Transform Immunotherapy Combination Treatment Landscape Through Targeted Delivery of Ultra High Potency Cytotoxic Payloads Directly to Tumor Sites

LOS ANGELES, Oct. 31, 2018 /PRNewswire/ -- CytRx Corporation (CYTR), a biopharmaceutical research and development company specializing in oncology, today highlighted that key emerging cancer treatment trends by Big Pharma, including combining immunotherapy with effective chemotherapy regimens, are resulting in significant advancements for the treatment of patients with high unmet medical need types of cancer. CytRx, along with its wholly owned subsidiary Centurion Biopharma, believe these trends strengthen and enhance the value proposition for their rationally designed albumin binding ultra-high potency anti-cancer agents.
(PRNewsfoto/CytRx Corporation)
(PRNewsfoto/CytRx Corporation)

Aldoxorubicin in Combination with High Affinity Natural Killer (haNK) Cells

Aldoxorubicin, CytRx's first albumin binding cytotoxic agent, was designed to increase the efficacy and overcome the cardiotoxic side effects of the anthracycline agent doxorubicin. In its clinical trials, aldoxorubicin demonstrated a significant improvement in progression-free survival compared to investigator's choice therapy in patients with certain types of soft tissue sarcoma. The rights to aldoxorubicin were acquired by NantCell, Inc. in 2017, and aldoxorubicin is now being investigated in clinical trials in combination with immunotherapy or NantCell's high-affinity natural killer (haNK) cell therapy in certain high unmet need cancer indications, including advanced squamous cell carcinoma, metastatic pancreatic and triple negative breast cancers.

"Among the most compelling recent medical advances by Big Pharma has been the efficacy seen when immunotherapy is combined with chemotherapy, especially in certain high unmet medical need cancers such as non-small cell lung and triple negative breast cancers," said Eric Curtis, CytRx's President and Chief Operating Officer. "In addition to finding better treatments for these patients, there is an equally urgent need for better cytotoxic agents, ones that can be administered in higher doses while avoiding the commonly associated toxicities. Aldoxorubicin was important to our pipeline because it achieved validating proof of concept for the albumin binding thesis and we believe that its target-specific drug delivery properties have the potential to enhance the effects of immunotherapy."

LADR™ Drug Candidates in Combination with Immunotherapy

Centurion BioPharma's LADR™ (Linker Activated Drug Release) technology employs a broad portfolio of novel linker molecules that selectively bind to circulating albumin and have the ability to be linked to a wide variety of anti-cancer payloads. Centurion's LADR™ drug candidates, LADR-7, LADR-8, LADR-9 and LADR-10, utilize the anti-cancer agents maytansine and auristatin E to maximize tumor cell kill potential while minimizing systemic toxicity. Centurion believes these agents have the potential to be combined with immunotherapies to improve the efficacy and safety of treatments for cancers that have typically been difficult to treat. At the American Association for Cancer Research (AACR) 2018 Annual Meeting, scientific research was presented which described the breakthrough data supporting Centurion's selection of its current LADR assets for advancement toward Investigational New Drug-enabling studies. These targeted compounds demonstrated excellent, long-term antitumor activity across a wide range of human solid tumor cancer types, including lung, breast, ovarian, head and neck, renal cell, and melanoma.


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