Monday, November 05, 2018 11:09:23 AM
Yes, I know what you're thinking "These drugs weren't developed because they didn't show enough activity" but you can never argue that w me for Folotyn plus romidepsin. I always remember the excitement I had watching the video of preliminary data presented by Dr. Owen O’Connor of the NYU Langone Medical Center 4yrs ago (https://vimeo.com/110122034) that showed it had great potential as a combo and thinking "Raj give Dr O'Conner a holler on developing this further" but to no avail. Who remembers the next Quarterly cc after that when Raj was asked a Q by an analyst about partnering (more or less alluding to this study) and getting a less than generic answer from Raj. See post 1566 for the more mature, and still promising ASH 2016 results (man, I was posting on ihub in 2016? how time flys!). Last time I checked there's several P2/P3 Romidepsin Plus Pralatrexate in PTCL trials posted on the web by NYU languishing to begin recruitment ( I hate to check these days, it gets me frustrated). Imagine if Spectrum got on the horn 4 yrs ago and got the ball moving on the combo study? I think that was a lost opportunity. So that's one of the reasons you may think I pick on Spectrum sometimes (Rolontis BLA in 2017 anyone?); I've seen them not execute and look for any signs of that happening now. Anyhows, pozi recruitment does seem to be going nicely except for the EU ;)
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