Friday, November 02, 2018 9:23:26 AM
1. Age - older patients tend to have fewer Tregs.
2. Tumor sizes.
3. The number of TIL at baseline for the combo. Remember, the predicted non-responder trial intentionally selected patients who were immunologically frozen, i.e. very few CD8 positive T cells with an exhausted phenotype.
I have not yet observed any combination with an anti-PD-1 that results in anything close to 30% in anti-PD-1 nonresponders in advanced metastatic melanoma, or any solid tumor cancers for that matter.
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