Thursday, November 01, 2018 11:33:27 AM
Because a chemical engineer without any education or experience remotely related to drug development or virology claims they "work"?
For what it's worth...
**Every** candidate anyone ever takes into IND and clinical development shows an extremely convincing therapeutic effect in laboratory experiments. Nobody would bother risking the millions of dollars to develop a candidate without such very strong preclinical evidence.
Yet, more than 90% of all such compelling candidates that "work" on cell cultures or animal models ultimately fail. So 90% don't ultimately "work" in the way that "work" is meaningfully defined for drug candidates.
If the data were anywhere near as compelling as Seymour and Diwan have claimed for the past 14 years, they would have developed candidates.
There is absolutely nothing about the chemical structures revealed in Diwan's patent to suggest they can't be manufuctured in sufficient quantities.
That Diwan himself, or people under his guidance, can't manufacture them in sufficient quantities speaks only to their lack of skill and experience in this highly specialized area of chemistry. It does not suggest there is some fundamental law of physics or chemistry in the way, or that a CMC pharma chemist with a few decades of experience in synthesizing nanoparticles in therapeutic areas couldn't easily do it.
A casual stroll through the lunatic asylum shows that faith does not prove anything. Friedrich Nietzsche
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