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DewDiligence

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DewDiligence

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Re: biotech_researcher post# 221697

Monday, 10/29/2018 10:12:53 AM

Monday, October 29, 2018 10:12:53 AM

Post# of 252308
Re: PFE-NVS clinical collaboration in NASH

From the same PR:

The companies will conduct both non-clinical and Phase 1 clinical studies of Pfizer’s investigational therapies, including an Acetyl CoA-Carboxylase (ACC) Inhibitor (PF-05221304, currently in Phase 2), a Diacylglycerol O-Acyltransferase 2 (DGAT2) Inhibitor (PF-06865571, Phase 1) and a Ketohexokinase (KHK) Inhibitor (PF-06835919, Phase 2), together with Novartis’s tropifexor, a non-bile acid, Farnesoid X receptor (FXR) agonist.

ICPT, GILD and ENTA are also testing FXR agonists in NASH.

The PFE-NVS collaboration does not include any direct cash transfers between the companies, evidently.

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