OncoSec Medical Inc (ONCSQ)

[hschlauch]

This publication is quite interesting for a multitude of reasons, but this is the main one:

It is the first time - quite unexpectedly from what I gather - that the abscopal effect generated by intratumoral administration of encoded IL-12 genes noticeably lacked exhaustion markers in tumor infiltrating lymphocytes found in untreated tumors. Typically this only happens during acute situations. If the new p2a-linked plasmid construct coupled with modified electroporation parameters has something to do with the significant improvements in intratumoral IL-12 expression and armoring of effector cells, then this is definitely a big deal. Obviously, just like everything else in immunology, the observations would need to translate into humans. But if it does, it could potentially negate the need for systemic anti-pd-1 agents!