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Sunday, October 21, 2018 8:07:13 AM
How about this:
Low concentration brilacidin IV once or twice a week combined with Brilacidin oral rinse to combat SOM. Currently, due to negligible absorption thru intact epithelium Brilacidin is active mostly in late stages of SOM development - preventing the spread of infection and reducing inflammation after ulcers have formed. Superoxides generated by radiation do cause cells to release proinflammatory agents well before that, but behind the wall formed by epithelium. Combination of oral rinse and IV might be able to reduce SOM incidences even further than rinse alone. And because Brilacidin has plasma half file about 20 to 24 hours it might be possible to administer IV only once or twice a week.
If I were BP I would be looking into possibility, if only because it could be the fix for weekly cisplatin problem. I have a reputation of being slightly off kilter... so, who knows, maybe I am grossly mistaken.
"I would rather have questions that can't be answered than answers that can't be questioned." Richard P. Feynman
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