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Re: None

Saturday, 10/20/2018 10:18:04 AM

Saturday, October 20, 2018 10:18:04 AM

Post# of 27648
Heterologous Tier 1 R5 SHIV-C Challenges: Correlates of Protection
Ruth M. Ruprecht, MD, PhD

1. Paired tier 2 and tier 1 clade C SHIVs with exclusive R5 tropism
2. Orientation of V2 and access to the CD4 binding site
3. Correlates of protection:
i. Anti-Env nAbs
ii. Cell-mediated immunity
iii. Protection-linked mimotopes
iv. An unexpected humoral correlate of protection

http://www.vaccineenterprise.org/sites/default/files/Ruth%20Ruprecht.pdf
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