rancherho:
"<<<It would seem to me that if one assumes the same treatment effect and event rate for 9902b as for the pooled 9901 and 9902a enrollees, the target p value threshold of 0.05 would be reached with substantially fewer events than if a Kaplan Meier derived p value was needed. Would this be true?>>>"
Seeing as no-one replied to this point, might I add that even more obviously you could assume a much lower treatment effect, on the order of 9902a's (log-rank) would be generally sufficient in a trial this size.
Of course another way of saying this is that the target (assumed) HR for success has been lowered.
"....on the biotech battle-field, you need some élan...."