Pluristem Therapeutics Inc (PSTI)

[FDApproved]

I Think I Know Why Pluristem Was Selected For Their Presentation At The American Heart Association Conference In Chicago On November 10th.

It Appears They Have Built A Strong Case Demonstrating That PLX-Cells Are Cardio Protective And Can Repair Damaged Portions Of The Heart.

Significance Statement

Impaired left ventricular (LV) diastolic relaxation represents the earliest preclinical manifestation of diabetic cardiomyopathy, a cardiac disorder with changes in cardiac structure and function in the absence of coronary artery disease and hypertension. Mesenchymal stromal cells (MSC) are well known for their cardioprotective features. This study demonstrates that intravenous application of placenta-derived MSC-like cells (PLX) improves LV diastolic relaxation and cardiomyocyte stiffness at an early stage of diabetic cardiomyopathy with low-grade inflammation and no cardiac fibrosis through increased titin phosphorylation. These findings offer new insights into the cardioprotective effects of PLX, advancing their potential use for cardiac therapies.

PLX Exert Antifibrotic Effects

Given the relevance of cardiac fibrosis in diabetic cardiomyopathy 1 and the antifibrotic potential of MSC 21, we further evaluated whether PLX also exert antifibrotic effects

PLX exert antifibrotic (scarring) effects in vitro. PLX conditioned medium reduces TGF-ß1-induced collagen deposition and a-SMA expression in cardiac fibroblasts

PLX Improve Vascularization in Streptozotocin-Induced Diabetic Mice


The salient finding of the present study is that I.V. PLX application reduces cardiomyocyte stiffness and improves LV diastolic relaxation in an early phase of STZ-induced diabetic mice. Endothelial dysfunction 16, impaired vascularization 3, microvascular inflammation 43, cardiac fibrosis 11, 12, and cardiomyocyte stiffness 15 all underlie impaired LV diastolic relaxation, one of the first clinical signs of diabetic cardiomyopathy.

Conclusion

In conclusion, i.v. PLX application improves LV diastolic relaxation and cardiomyocyte stiffness at an early stage of diabetic cardiomyopathy through increased titin phosphorylation. These findings offer new insights into the cardioprotective effects of PLX, advancing their potential use for cardiac therapies.



https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/sctm.17-0130