Pluristem Therapeutics Inc (PSTI)

[FDApproved]

Another Great Find PLX-11 ! One Can Easily See How PLX-R18's Unique MoA Is Going To Have Broad Implications For A Myriad Of Indications. PLX-R18 Cells Have Been Evolutionarily Programed To Respond To Stress Signals From The Body So They Can Release The Correct Secretome To Repair An Organ Or A System. Incredible I Have Always Said It Sounds Like Science Fiction But In Fact It Has Been Taking Place Inside Every Healthy Human Placenta For Hundreds Of Thousands Of Years And Beyond ! "TALK ABOUT HARNESSING A DISRUPTIVE TECHNOLOGY ! This Is Going To Change The World Of Medicine IN A BIG WAY ! NO DOUBT ABOUT IT ! Nice To See This Study Publish In The Cachexia/Sarcopenia Journal, 2nd One In A Few Weeks, They Are Gearing-Up For Something Big IMO ! Let's Hope So !

"Remarkably, when the PLX-RAD cells were injected IM in the same manner in naïve non-irradiated mice, only negligible levels of the PLX-RAD secreted human proteins were detected in the plasma (with very limited short-term elevations of IL-6, MCP-1 and Fractalkine). This suggests that the systemic stress signals related to ARS stimulate the IM injected PLX-RAD cells in the acute phase in which they were needed to trigger the controlled transient co-secretion of these proteins to the circulation in a manner in the acute phase in which they were most needed." (Figure 3B–J).


The data on the pro-regenerative secretome of the PLX-RAD cells in response to stress may have implications for other wide range of regenerative therapies. Muscle regeneration by stem/progenitor cell recruitment, proliferation and survival are supported by the inflammatory cells which are affected by the PLX-RAD cell secretome in response to ARS.

We can hypothesize that the mechanism of PLX-RAD effects may be related to their possible physiological role in the placenta, where they respond to messages carried by the embryo circulation, potentially serving as both sensors and responders to its stress signals and as secretors of pro-regenerative proteins. In the current study which is focused on short-term follow-up of acute effects of less than 8 Gy irradiation, no muscle damage was expected. But in other degenerative processes, the haematopoietic system is recruited by the PLX-RAD secretome, boosting different haematopoietic lineages including eosinophils, macrophages and T cells. In such circumstances, the induced secretome of potent PLX-RAD cells may participate in the regeneration of tissues such as damaged muscles,86-88 an issue which deserves further investigation.

In summary, we provide detailed mechanistic insights into simple well-regulated allogeneic/xenogeneic PLX-RAD cell-based treatments. The mode of action of these cells in mitigation of ARS following high dose irradiation is based on the induction of a faster regeneration of highly damaged or depleted BM, thus reversing subsequent life-threatening pancytopenia and severe weight loss.

https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12342