RespireRx Pharmaceuticals Inc (RSPI)

[K-G]

nerdseeksblonde,
Thank you for the response. Histologic, Toxic, Reversable, Asymptomatic, and Never-Before-Seen... I'm not knowledgable enough to judge, but it does seem to be quite the puzzle. The type of tissue where the phenomenom is observed was not disclosed. There was some speculation in earlier postings that it was in brain tissue. I think there was also an assumption that the effect was visually observed in thin sections, though I do not recall anything that specific stated in the CC. I haven't a clue whether there would be any more specific tests of tissue samples, nor if many organs from the courageous volunteers would be sampled. I suppose they might notice the effects of some histologic changes indirectly (e.g. too much intercellular H2O concentrations indicating affected astrocytes), but it is hard for me to believe that there was a visually identified brain cell pathology that was completely asymptomatic.

My initial guess was that they observed some hepatic pathology, but that would not fall into the Never-Before-Seen catagory, especially since it was observed only at extemely high dosages.

I think your suggestions that some change in osmosis or some other uptake mechanism causes a temporary cell size change. During the CC I think there was some discussion of whether multiple cell or tissue types were involved, but I think it was a single tissue type with some evasion on whether multiple cell types were involved. I suppose it is possible to have some cellular hypertrophy in some brain cell type that would be asymptomatic. But, would such a phenomenom be considered toxic?

Your suggestion to imagine storage granules is more interesting. I can easily imagine the accretion of some material (extracellular protien crystals, to the walls of something, ???) in the presence of exceedingly high concentrations of some compound that meets the Never-Before-Seen requirement, but again, would that be considered toxic.

Well, thank you again. All this tells me is that I need to go back to school!!!