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$MCET Multicell Immunotherapeutics, Inc.: 75000 shares Selling Stockholder of GTBP Gt Biopharma Inc.

The date of this prospectus supplement is September 21, 2018.

Settlement Agreement

On September 8, 2018, we entered into a Confidential Settlement Agreement and Release, or the Settlement Agreement, with Multicell Immunotherapeutics, Inc., or Multicell, to settle a breach of contract lawsuit. As part of the Settlement Agreement, we agreed to issue to Multicell 75,000 shares of Common Stock at an agreed value of $2.00 per share. Multicell is a selling stockholder. For purposes of the table below, beneficial ownership is based on the securities held of record by the selling stockholders as of May 11, 2018.

https://ir.gtbiopharma.com/all-sec-filings/content/0001654954-18-010380/0001654954-18-010380.pdf