Innovation Pharmaceuticals Inc (IPIX)

[georgejjl]

Dare to compare Prurisol to Otezla (Apremilast)

Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: Efficacy, safety and tolerability results from a phase 2b randomized controlled trial.
Ohtsuki M1, Okubo Y2, Komine M1, Imafuku S3, Day RM4, Chen P4, Petric R4, Maroli A4, Nemoto O5.
Author information
1
Jichi Medical University, Shimotsuke, Japan.
2
Tokyo Medical University, Tokyo, Japan.
3
Fukuoka University, Fukuoka, Japan.
4
Celgene Corporation, Summit, New Jersey, USA.
5
Kojinkai Sapporo Skin Clinic, Sapporo, Japan.
Abstract
Apremilast, an oral, small-molecule phosphodiesterase 4 inhibitor, works intracellularly within immune cells to regulate inflammatory mediators. This phase 2b randomized, placebo-controlled study evaluated efficacy and safety of apremilast among Japanese patients with moderate to severe plaque psoriasis. In total, 254 patients were randomized to placebo, apremilast 20 mg b.i.d. (apremilast 20) or apremilast 30 mg b.i.d. (apremilast 30) through week 16; thereafter, all placebo patients were re-randomized to apremilast 20 or 30 through week 68. Efficacy assessments included achievement of 75% or more reduction from baseline in Psoriasis Area and Severity Index score (PASI-75; primary) and achievement of static Physician Global Assessment (sPGA; secondary) score of 0 (clear) or 1 (minimal) at week 16. Safety was assessed through week 68. At week 16, PASI-75 response rates were 7.1% (placebo), 23.5% (apremilast 20; P = 0.0032 vs placebo) and 28.2% (apremilast 30; P = 0.0003 vs placebo); sPGA response rates (score of 0 or 1) were 8.8% (placebo), 23.9% (apremilast 20; P = 0.0165 vs placebo) and 29.6% (apremilast 30; P = 0.0020 vs placebo). Responses were maintained with apremilast through week 68. Most common adverse events (AEs) with placebo, apremilast 20 and apremilast 30 (0-16 weeks) were nasopharyngitis (8.3%, 11.8%, 11.8%), diarrhea (1.2%, 8.2%, 9.4%), and abdominal discomfort (1.2%, 1.2%, 7.1%), respectively. Exposure-adjusted incidence of these AEs did not increase with continued apremilast treatment (up to 68 weeks). Apremilast demonstrated efficacy and safety in Japanese patients with moderate to severe plaque psoriasis through 68 weeks that was generally consistent with prior studies.

See more information at:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573969/

Within just 84 days 46% of patients receiving 200mg per day of Prurisol with “moderate” psoriasis achieved IGA 0/1

THAT IS AMAZING!!!

Click on the image below:



http://www.ipharminc.com/prurisol-1/

Good luck and GOD bless,


George