Xechem International Inc. (fka XKEM)

[Diamond_Dog]

To all that wish we had our own Scientific BIO wizard...
your prayers have been answered....

I was chatting with socal_helix from over on the PP
board and he has graciously offered his expertise
with any questions that might arise as far a anything
involving : BIO TECH INFO

Just a little about socal_helix:

He is a PhD scientist from San Diego and has been in the drug dicovery industry for 11 years in various biotech and or pharmaceutical companies.

He does read Ihub but doesn't post here.

I would assume that if you were to post
a question here it would be answered either
by a repost from PP or posted right on
Ihub.



A sample post from PP


Joined: 13 Jun 2006
Posts: 88
Location: San Diego
Posted: Tue Oct 24, 2006 7:31 pm Post subject:



EVERY SINGLE drug company on Earth aims to have their compound in pill form, it's generally thought that intraveneous versions aren't "sexy" and mainly an unwanted option. I, personally, have seen many compounds go undeveloped simply because the compound's molecular structure, and it's effective dose would render it impossible to stuff into a pill form, (there's other things that go intoa pill, carrier molecules, stablizers, etc) so development was haulted and a search for it's analogue (another similar version of the compound) that can be put into pill form was pursued.

Drug screening, in a SMALL nutshell, consists of developing a "model" in vitro/ in vivo biological system. Using that system we screen MILLIONS of compounds and generate lists of "hits." A secondary ( and tertiary) screen is performed to eliminate false postives and to validate the true positives. Long story short, when we find a great compound, then we make THOUSANDS of chemical derivatives (analogues) that are extremely similar in structure, maybe change an "R" group here and there so the compound maintains or improves it's efficacy, but also possesses what's considered the general rules as to what constitutes a "drug," molecular weight, rotatable bonds, etc.

The fact that 5-HMF is taken through the blood directly most LIKELY means it demonstrated much higer efficacy, speceficity for it's molecular target and was worth pursuing even though it had the less than "sexy" means of delivery...injection. It must have had great results, or there just wasn't any other option out there in the world that dsiplayed similar benefits and patients will tolerate a needle poke if it means living.

From what I can see, Nicosan doesn't perform AS WELL....not bad, just not AS WELL as 5-HMF. But Nicosan STILL outperforms....by FAARRR, any other drug out there, aside from it's cousin, 5-HMF.

Thanks social_helix


$$Good Luck$$

J...............