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InTheTrenches

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InTheTrenches

Re: XenaLives post# 6734

Wednesday, 08/29/2018 3:18:21 PM

Wednesday, August 29, 2018 3:18:21 PM

Post# of 21540
I've already looked. Trajectory of patients in AVXL's last trial follows the same MMSE decline as historical placebo.

Predicting approval based on cherry-picking results from a non-placebo controlled trial is a recipe for disaster.

NTRP, in spite of drug-to-drug interaction, still saw an improvement of SIB scores in the on-drug arms in a placebo-controlled trial. Sub-group analysis of non-memantine patients saw statistically significant improvement (p=.012) in SIB scores in bryostatin patients.

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