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Saturday, August 18, 2018 10:40:31 PM
Celgene had a small Phase 2 trial for Otezla (apremilast, CC-10004) there were only 30 subjects in the treatment phase.
...the proportion of subjects achieving PASI 75 was 30%....
...9 subjects achieved PASI 75....
...several subjects (4) dropped out early (on or prior to week 4) due to intolerability (gastrointestinal effects) or withdrawn consent....
That is very similar to the proportion of subjects achieving
PASI 75 in the larger Otezla Phase 4 trials.
https://media.celgene.com/content/uploads/CC-10004-PSOR-004-Synopsis-Redacted.pdf
Now compare those results to the Prurisol Phase 2 trial results.
https://static1.squarespace.com/static/5715352e20c647639137f992/t/583ddc8303596e5fc7e8bf06/1480449160455/Cellceutix_Corporate_Slide+Deck_DERMATOLOGY_November+2016+Website+Vers.pdf
Good luck and GOD bless,
George
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