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fcmboca   Monday, 08/06/18 04:51:32 PM
Re: never-say-die post# 48958
Post # of 50559 



1. Peracetic acid has been used for decades as a bleaching agent in the pulp industry. It is well known in that industry as well as the health care industry as a cleaning agent for stethoscopes, blood pressure cuffs etc.;


2. It has the same oxidizing potential as H2O2 of 1.8 and at high concentrations can achieve a 4 log kill for most bacteria;

Quote: “…after which the room was exposed for ~8 minutes to the dilute peracetic acid-hydrogen peroxide aerosol. After scavenging the aerosol and the surface had dried (<1 hour), we sampled each exposed duplicate inoculated site and again found total sterilization, most impressively, even with 10,000 spores of C.difficile.”


Dennis G. Maki, M.D.
Dr. Maki is the Ovid O. Meyer Professor of Medicine, Head of the Section of Infectious Diseases at the University of Wisconsin Medical School in Madison, Wisconsin, and Attending Physician in the University of Wisconsin Center for Trauma and Life Support. In his activities as an infectious disease consultant, intensivist and hospital epidemiologist, Dr. Maki has devoted his research career to the study of pathogenesis, diagnosis and prevention of nosocomial infections, particularly bloodstream infections caused by intravascular devices and the management of septic shock and other life-threatening infections. A past consultant to the CDC, NIH, FDA and HHS, he is a former President of the Society for Healthcare Epidemiology of America and Councillor of the Infectious Diseases Society of America. From 1987 to 1994, he was a member of the ICAAC-ASM Program Committee and from 1989 to 1995, served on the ABIM Board of Critical Care Medicine. Dr. Maki has won numerous awards for teaching at the University of Wisconsin and nationally. In 1994, he received the CIPI Award of the International Congress on Infection Control, Societe de Pathologie Infectioense de Langue Francise, the World Health Organization and the CDC, for his contributions to the prevention of infection. In 2000, he was made a Master of the American College of Physicians and received a Society Citation from the Infectious Diseases Society of America for lifetime contributions in the field of infectious diseases. In 2001, he received the Hilldale and the Belzer awards from the University of Wisconsin for achievements in teaching, research and service. Following the events of September 11, 2001, Dr. Maki was appointed to the Wisconsin Medical Society Taskforce on Bioterrorism, the Governor’s Bioterrorism Preparedness Task Force and as a consultant for the National Response to Bioterrorism of the Centers for Disease Control; in 2002, he named to the U.S. HHS Secretary’s Council on Public Health Preparedness.



3. Ozone has an oxidizing potential of 2.1 and at high concentrations can achieve a 4.5 log kill for most bacteria;

Quote: “At 50-180 ppm ozone, bacterial kill was negligible; however, at 500 ppm ozone, there was a >6 log reduction in bacteria compared with the unexposed control discs (Table 1).” (emphasis mine)

Effectiveness of a novel ozone-based system for the rapid high-level disinfection of health care spaces and surfaces
Dick Zoutman, MD, FRCPC,a Michael Shannon, MD, MSc,b,c and Arkady Mandel, MD, PhD, DScc
Kingston, and Ottawa, Ontario, Canada


4. Trioxidane, which is derived by mixing ozone and peroxide, has an oxidation potential of 2.8 and is only exceeded by fluorine, which has an oxidizing potential of 3 (very dangerous). With this extremely high oxidative potential, trioxidane can readily achieve 6-7 logs of kill for all bacteria including both aerobic and anaerobic spore formers such as Clostridium difficile and Bacillus subtitles (surrogate for anthrax) in biofilms; and (emphasis mine)

Quote: "More studies are needed to examine the applicability and compatibility of this system in actual hospital facilities, such as operating rooms, patient rooms, laboratories, and morgues, and with the materials and equipment that might be exposed to this ozone-based disinfection process." (emphasis mine)

Effectiveness of a novel ozone-based system for the rapid high-level disinfection of health care spaces and surfaces
Dick Zoutman, MD, FRCPC,a Michael Shannon, MD, MSc,b,c and Arkady Mandel, MD, PhD, DScc
Kingston, and Ottawa, Ontario, Canada


5. Although peracetic acid (the basis for Altapure) may be marginally effective in an empty room or on non-electronic equipment such as stethoscopes, its effects on sensitive electronic devices is unknown and our engineers advise that it cannot be used to sterilize circuit boards during manufacturing.

Attack Agent Independent: The Altapure ultrasonic system can aerosolize various agents including PPA, H2O2, Enzymes, etc.; it is not limited to a single agent as are vaporized hydrogen peroxide (VHP) systems. This feature will provide flexibility to aerosolize future chemical agents.

Agent Versatility: The dispersal system can be configured to output PAA and an enzyme from the same piece of equipment in sequence and at differing droplet sizes. The PAA will be effective on bio- agents and the enzymes effective on chemical agents including pesticides.

Corrosiveness: A 1% PAA solution has been shown not to effect materials found in the typical hospital setting including electronic equipment such as computers, printers, scanners etc. PAA is used to disinfect endoscopes and is currently used in hospitals to clean various surfaces by the “dip-wipe and drop” method. PAA has been widely used for over twenty years.




The key difference here between peracetic acid and trioxidane is the 33% increase in oxidizing potential of Trioxidane, which is supported by its unmatched efficacy across all pathogens in a manner virtually to that of the human body. It is also noteworthy that there has been no published data on bacterial kill with peracteic acid either in the laboratory or complex settings of a hospital . We could not find any peer review or published research to support the Altapure claims of 100% kill (>6 log) and the well established differences in oxidizing potential (1.8 vs 2.8) would draw into question the validity of their claim.

@@@@@ Raven Labs Validation Report @@@@@



As a leading infectious disease specialist, researcher and author of hundreds of articles in this area, Dr Zoutman is familiar with almost all imaginable systems for hospital disinfection (see slide presentation attached). This system as a means of decontaminating hospital spaces and content is unfamiliar to members of the Ontario Infectious Disease Control Committee (chaired by Dr Zoutman).


On TUESDAY, JUNE 1, 2010 Dick Zoutman gave an oral presentation at the Community and Hospital Infection Control Association (CHICA) NATIONAL EDUCATION CONFERENCE on the “EVALUATION OF THE EFFICACY OF STEAM DISINFECTION Of IN-VIVO HOSPITAL SURFACES”

The exhibitor at BOOTH/TABLE 213 that same year was:

Altapure Canada Inc.
3035 Larkdowne Road
Victoria, BC V8R 5N3
“dry fog” technology for large-scale cold disinfection.
100% kill without exposure limits, toxic residue, or
residual moisture. fast, cost-effective, safe, and simple to use.


It is always suspicious when a company in this field does not have any medical professional voice on staff. They have clearly not taken the normal road toward obtaining recognition with the scientific and medical community which has clear established pathways to validation; i.e. documented and published scientific studies, peer review journal research, presentations at medical conventions.


Without published data that has been verified by outside sources it is hard to imagine them every gaining traction. With an oxidation potential only 60% of that for Trioxidane, it is difficult to imagine how they could become competitive. Both approaches are "green" and both (as best we can tell) may be comparable in terms of time, but both systems are not comparable in terms of efficacy."

Raven Labs Validation Report



VAN NUYS, Calif., June 5, 2012 - ITT Exelis (NYSE: XLS) and Altapure, LLC are launching a new model of their state-of-the-art disinfection system at the Association for Professionals in Infection Control and Epidemiology annual conference this week in San Antonio, Texas.

The two companies have worked jointly for the past seven years to develop a portable nebulizer that eradicates viruses, bacteria, spores and fungi in less than 10 minutes. The Exelis technology enables the ultrasonic subsystem of Altapure’s nebulizer to deliver a robust, dense cloud of sub-micron droplets, providing high-level disinfection or decontamination of large areas. The first application of the technology has been in medical centers where cleanliness and patient safety are paramount.

The initial Altapure system has been successfully piloted in targeted hospitals during the past year, and the new model, the HJ-30i, delivers major breakthroughs in size, weight, performance flexibility and scalability.



“In all the testing that I have done over the years at Raven, I have never seen any method kill both G. stearothermophilus and B. atrophaeus in less than fifteen minutes and yours was showing all killed in less than a minute. I was floored.”

Deb Dwyer
Director of Operations, Raven Labs



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