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Tuesday, July 24, 2018 11:41:21 AM
Assuming that phase 2b trial is successful and shows at least the same efficacy as phase 2a trial did. Then
1. Oral adminstration
2. More effective than most other non-biological treatments for psoriasis. Depending on the level where prurisol efficacy settles at, methotrexate (cytotoxin) or cyclosporine (IARC Group 1 carcinogen) might still be more effective.
3. With proper patient screening (some people are allergic to abacavir which is the main metabolite of prurisol) has few side-effects (definitely less than methotrexate, cyclosporine or Otezla) and, so far, no evidence of immunosuppression which is the major concern with almost all biologicals.
4. Currently no evidence of the loss of effectiveness over time.
"I would rather have questions that can't be answered than answers that can't be questioned." Richard P. Feynman
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