Synaptogenix Inc (SNPX)

[InTheTrenches]

From memory: In Memantine trials, I believe Memantine improved SIB score by 1 point in the first ~4 weeks vs. a decline in SIB of 1(?) point for placebo.

However, Memantine and placebo arms declined in a similar trajectory by the end of the trial (6 months). That is, at the end of the 6 month trial, both Memantine and placebo had declined in SIB score but Memantine had declined less.

I believe Donepizil, the other approved drug, is viewed slightly more favorably. It was approved before Memantine. It is similar to Memantine, in that AD patients on Donepizil still decline in SIB score in the long-run, but less than placebo.

Also, the 2 drugs together work better than either separately, but some AD patients can't tolerate the side-effects of one or the other.