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Re: DesireToLearn post# 234892

Thursday, 07/19/2018 6:00:11 PM

Thursday, July 19, 2018 6:00:11 PM

Post# of 403047
Sure, at least I can try. First, it is my belief that PASI 75 response needs to be above 25 %. Second, if prurisol PASI 75 response is about 25 % then placebo PASI 75 response should not exceed 15 % for p value to remain below 0.05. That gives us response ratio of 25/15 or 1.67. Hence, with the headcounts IPIX has in phase 2b trial failure is very, very likely if the response ratio prurisol/placebo falls below 1.65 (approximately). It think it is neater to say it this way than playing with percentage ranges.

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