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Re: snack post# 90076

Thursday, 07/19/2018 2:07:37 PM

Thursday, July 19, 2018 2:07:37 PM

Post# of 205107
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314037/

IgG is a valid FOOD INTOLERANCE test but questionable for FOOD ALLERGY test as its level may be normal human response in certain demographics.


The detection of food-specific IgG shows a physiologic response of the immune system to exposure to food. For IgG4 in particular, this may be the normal human response.5 Immunoglobulin G antibodies directed at specific foods can be found in healthy children as well as adults.6 Higher levels of IgG4 to foods in infancy may be associated with tolerance to those foods later in childhood.7

The relation between IgG4 and food has been further explored through the recent developments in oral immunotherapy to foods. Efforts to induce permanent tolerance to allergens such as milk or peanuts have been accompanied by increases in patients’ IgG4 levels to those foods.8 Therefore, IgG4 is believed to be a marker of exposure to food and possibly of tolerance.5 Further research is required to clarify any role for specific IgG measurement in the assessment of a patient with potential food allergy.