nearlynapping, I vote #4. These guys should have begun their research under the auspices of a large medical school or state university with deep pockets. When they found success they could then license their patents, INDs, etc. and sell their management/scientists to companies that can take the discoveries to market and who know how to run a business. All parties involved would benefit and the public, i.e. us, could then invest in great ideas backed by strength and talent. The start-up guys would have only made about a third of what they have made off the stockholders of CYGX on an annual basis, but may have made out just as well in the long run if the science is good. Once the science has been proved and approved, then the BIG payday. Not the way these guys have done it. (and IMHO big pharma would be stalking CYGX if the science was good-no signs of it!) Take care and good luck.