Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

Those conversions are only used for determining a safe starting dose in any escalating safety trial. Phase 2 includes safety at escalating dosages to determine optimal dosing range. Published studies on mouse to human conversions recommend not using it without human data and to never use it to determine expected efficacy ranges. In the case of P, there already exists 20 years of human use for drugs that are salts of Abacavir and reduce to abacavir.

And, yes, we know the doses administered to mice. They were published long ago.