Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

Thanks BioDoc. Obviously preclinical stuff is anything but my strong suit, hence absolute ignorance of mouse to human conversion formula. I am going to save your response!

This is my take from your answer:
1. There is therapeutic threshold for prurisol plasma concentration and it is somewhat higher than the concentration that can be achieved with 50 mg oral dose but below that from 100 mg oral dose.
2. Reponse saturation at 100 mg BID dose cannot be ruled out because we don't have even mouse results for equal or higher doses.

comment about tox:
600 mg daily max goes hand in hand with 8 mg/kg BID and 16 mg/kg QD dosing in pediatric use. Could it be that toxicity is no major concern with adult doses up to 600 mg BID or 1200 mg QD?