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Friday, June 29, 2018 11:04:09 AM
Just for clarification.
Any difference can be shown to be statistically significant with large enough trial. The difference between survival rates 67.0 % and 66.0 % at 24 months can be shown to be statistically significant with a really large trial (~ 40000 subjects). But is the difference clinically meaningful?
Conversely. Most of us would agree that 138 % difference in response rates is clinically meaningful. But it will not be statistically significant in a trial with 60 subjects. As we have seen in prurisol 2a trial.
"I would rather have questions that can't be answered than answers that can't be questioned." Richard P. Feynman
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