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Re: KMBJN post# 232664

Friday, 06/29/2018 11:00:46 AM

Friday, June 29, 2018 11:00:46 AM

Post# of 403222
KMBJN, I'm on the same page. A reminder that the Primary Outcome Measure for PASI 75 has a timeframe of 12 weeks in this Prurisol Phase 2b trial whereas other trials (e.g. Otezla) focused on a 16 week timeframe. With an earlier timeframe, 20-30% PASI 75 with a high single digit placebo rate would be great.

The science hasn't changed though the bashing has been incessant. Pre-clinical data with an excellent and highly predictive animal model along with signs of efficacy at 200 mg, a few interesting database tidbits courtesy of PlentyParanoid and I believe there's a high likelihood of success for this trial. Obviously, PASI 75 over 30% with a shorter endpoint timeframe and a well-tolerated drug would be blowout good.

biodoc


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