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NY1972

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NY1972

Re: A deleted message

Sunday, 06/24/2018 9:29:34 PM

Sunday, June 24, 2018 9:29:34 PM

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Some disadvantages of viral vectors:

Neutralizing antibodies develop with subsequent vaccinations;
recipients of vaccinia (smallpox) vaccine have pre-existing immunity to vector
Replication-competent virus (VV), not appropriate for use in immunocompromised patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207353/
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