Opko Health Inc (OPK)

[terry hallinan]

Biomarkers/Epidemiology/Outcomes - presented at ASCO

https://tinyurl.com/yb36twku

I probably don't need to tell anyone here that ASCO is the premier scientific showcase of cancer treatments presented in America and probably the world.

A pre-specified statistical model based on four kallikrein markers in blood to predict advanced pathology on radical prostatectomy.

This is a presentation of the 4kscore test followed by:

Analysis of genomic alterations in matched circulating tumor cell DNA (CTC DNA) and plasma tumor DNA (ctDNA) in men with metastatic castration resistant prostate cancer (mCRPC)...

Detailed Description:
The study will construct a multi-center clinical database of men before and after treatment with abiraterone acetate, enzalutamide, and taxane chemotherapy, and will comprehensively analyze CTC DNA for copy gains/losses and whole exome sequencing for acquired mutations, CTC RNA for AR-variants and evidence of epithelial plasticity, and plasma circulating tumor DNA (ctDNA) for whole exome sequencing. Significantly, the investigators will pair the presence of key proposed circulating biomarkers of treatment resistance with patient outcomes on these systemic therapies for the purpose of developing predictive biomarkers that may have direct clinical utility in guiding choice of therapies....

Ahhh, what the joys of being a medical experiment must be.

https://tinyurl.com/ybvrgdyw

Much of this has been done before but even the like of Warren Buffett in his 80's when the vast majority of men have indolent prostate cancer panicked at the terror word cancer and demanded a radical prostatectomy against his doctor's advice according to the doc.

Are your president and your congress critters and lawyers pining to be judges better at reading scientific abstracts and white papers or amounts of dollar in political contributions?

Doesn't seem to me even a close call but wasn't Frost astute enough to know all that?

That is left as homework for the reader.

For myself, I sure hope Frost wins but that's not what I bet on.

Best, Terry