Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

U shape dose vs PASI 75 response curves are rare. I know exactly one: Can-Fite's piclidenoson managed that with doses 1mg-2mg-4mg BID, the best and only good PASI 75 response was with 2 mg dose. More common is saturation; after certain point PASI 75 response stops growing with increased dose. Taltz is a good example of that - no benefits from going over 80 mg Q2W.

The above in mind a conservative estimate for prurisol doses 300 and 400 mg is PASI 75 response around 30 %, or the same as for 200 mg. That is good enough.

Additional things working in prurisol's favor:
1. Prurisol's phase 2a response percentage ( ~32 %) was for sPGA 0/1 with at least 2 point shift. Historically PASI 75 response is about 10 % higher than sPGA 0/1 response.
2. PASI 75 and sPGA 0/1 responses for subjects with moderate to severe psoriasis are usually higher than corresponding responses for subjects having mild to moderate psoriasis. This has to do with how both these measures are constructed.

And the thing making me a bit jumpy: we have only one good data point so far, at 200 mg dose in a small trial. One point does no trend make - could have been a fluke, although I have some good reasons to believe that a fluke is not in the cards. We'll see. Soon. Hopefully.