Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[nep2134]

Here's one source, Cayman Chemical, https://www.caymanchem.com/product/11001 No idea who they are, or the quality of the product, but they want $350 per 100mg. Have to inquire for bulk pricing. But what makes theirs worth $3.50 per mg when you can get it retail for 31 cents and ready to take?

Maybe because they are just doing small batches? Looks like they ship it as a liquid in an ethanol solution and it is shipped cold, in wet ice. Recommends storage at -20C and it is stable for at least 1 yr. So as you can see, pure anatabine doesn't appear to be chemically stable at room temps which is why it is sold as a salt like citrate. And for longer term storage should probably keep any anatabloc in the frig or possibly even the freezer.

And then they sell it as a tartrate at $770 per 100mg. Ships at room temp and recommends -20C storage with stable for 2 yrs or more. Here's their description.

Comments
(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid beta (Abeta) production in vitro and in vivo. (R,S)-Anatabine reduces (600 µg/ml) the transcription and protein levels of beta-secretase, lowering the amount of Abeta1-40 and Abeta1-42 in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-kappaB activation.