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Re: RockRat post# 35619

Monday, 10/16/2006 3:26:44 PM

Monday, October 16, 2006 3:26:44 PM

Post# of 253146
ENCY – The warfarin interaction remains an issue, IMO. From your SI post:

>>
The AUC0-inf of S-warfarin (25 mg) increased with sitaxentan administration with 95%, for 100 mg once daily doses of sitaxentan (study FNL02). Also the terminal half-life of warfarin increased after sitaxentan co-administration.
<<


he is correct but it is manageable. they reduce the dose of warfarin to manage the interaction. The fda should be more concerned with the higher lft's of tracleer and the fact that people can stay on the drug for a longer period of time
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