Powerball numbers for 04/21/2018 are: 40 50 54 62 69 Powerball 19 Powerplay 2X The estimated Grand Prize was $142,700,000 ($85,200,000 cash). There was no Grand Prize Winner. The next Powerball drawing will be on Wednesday, April 25th, 2018 with an estimated Grand Prize of $158,000,000 ($94,300,000 cash). http://www.powerball.com/pb_home.asp