Innovation Pharmaceuticals Inc (IPIX)

[PlentyParanoid]

Inifity, we don't know if there were any sPGA 0 / PASI 100 responses in prurisol 2a placebo arm. IPIX did not break placebo arm down the same way as they did with prurisol arm. What we have is sPGA 0/1 response of 4 out of 30 subjects (7 sPGA = 2 and 23 sPGA = 3 at baseline) or 13.3 % sPGA 0/1 response rate. That is not unheard of. For example, baricitinib phase 2 trial recorded the following placebo responses for 34 subjects:
sPGA 0/1 14.7 %
PASI 75 16.7 %
PASI 90 2.9 % or one subject
No reported values for placebo sPGA0 or PASI 100% but judging from 2.9 % for PASI 90 those clear skin responses were probably 0. And that is how it goes. There is usually a steep drop off in placebo responses from PASI 75 / sPGA 0/1 to PASI 90 and then from PASI 90 to PASI 100 / sPGA 0.

BTW, Lilly just re-filed baricitinib. It scored nice 54.1 % PASI 75 response at 10 mg QD oral dose. Probably will be the next oral drug on market to have PASI 100 response over 10 %. Luckily for prurisol it is an immunosuppressive biologic JAK inhibitor (like Xeljanz).