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biophud

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biophud

Re: DewDiligence post# 2267

Wednesday, 10/11/2006 1:37:01 PM

Wednesday, October 11, 2006 1:37:01 PM

Post# of 4764
Dew-Question about anti-VEGF. Genetech uses an antibody fragment for AMD. Imclone also has developed an anti-VEGFR-2 Fab (see link).

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&l...

Are manufacturing concerns/costs the primary reason to use an antibody Fab rather than full length IgG? Or is there a scientific reason why the full length would be undesirable in AMD due to activation of antibody effector functions? Full length IgG should have a longer half life. Is Genetech on good scientific grounds when they warn against using Avastin for AMD? Any thoughts/comments would be appreciated. Thanks in advance.

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