GTC Biotherapeutics (fka GTCB)

[gym gravity]

I think it would be significant. If they developed a few strains of goats, each one with different levels of oligosaccharide ligases glycosylases expressed in the endoplasmic reticulum and golgi of the mammary glands, they could cross a transgenic goat expressing a protein of interest into these different strains to generate differentially glycosylated proteins. It is much more subtle than mutating a glycosylation site, and once the goat strains are established, doesn't require additional nuclear transfer/cloning. What you suggest requires nuclear transfer for each point mutation.

I think this is the secret that caused Merck to buy Glycofi. It isn't that Glycofi has yeast with all the human enzymes, it is that they can control glycosylation and select the conditions (strains) that produce the best bioactivity or pharmacokinetics for a particular protein.