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Tuesday, February 27, 2018 1:17:09 PM
Hahaha wow!!
Yep, that was exactly what the FDA said to Kempharm when they requested an abuse deterrent label for their prodrug, Apadaz. If you know of any pro-drug opioids that actually work as intended and are abuse-deterrent, please share.
Kempharm's studies show that there is a decrease in plasma concentration when *EIGHT* (8!!!) tablets are taken. In other words, not much help
I thought preventing dead by lowering the concentration in plasma was good... I guess I was wrong ;)
So by the standards you describe, a drug should be described as having overdose protection if there is no change for the first 7 tabs and a mild reduction in plasma conc if an 8th tab is taken. Got it. Good luck with your investment.
Call on God but row away from the rocks.
-Hunter S. Thompson
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