Innovation Pharmaceuticals Inc (IPIX)

[georgejjl]

Prurisol for the treatment of breast cancer, psoriasis, arthritis, heart disease (atherosclerosis), multiple myeloma, autoimmune diseases, etc.

Prurisol (abacavir gylcolate) is a small molecule (<500 molecular weight) that is an ester of Abacavir (abacavir acetate). It acts through immune modulation and PRINS — Psoriatic-associated non-protein coding RNA Induced by Stress — reduction, lowering IL-20 and skin cell proliferation rates.

http://www.ipharminc.com/new-blog/2017/6/1/prurisol-for-psoriasisan-overview

IL-20 is a pleiotropic cytokine involved in cancer, atherosclerosis, rheumatoid arthritis, and stroke. IL-20 has recently been reported to play a pivotal role in tumor progression, and its expression has been strongly associated with the clinical outcomes of breast cancer patients

In summary, our findings have shown that IL-20 expression in breast cancer is regulated by a transcriptional complex composed of transcription factors, including ER(a), GATA3, and FOXA1, as well as a transcriptional elongation factor, Ell3 (Figure ?(Figure5).5). Recent evidence indicates that IL-20 is a therapeutic target in various cancers, including breast cancer, and that an anti-IL-20 monoclonal antibody has therapeutic potential for alleviating inflammation and osteolysis associated with tumor progression [9, 13, 15, 16]. Therefore, we expect that the results of our study will facilitate the development of a new therapeutic strategy for targeting IL-20 expression in various diseases, including cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522103/

Good luck and GOD bless,

George