Thursday, February 15, 2018 7:51:51 AM
Breath testing is most frequently utilized by law enforcement officials, but this technology may offer much wider application. THC was first reported in breath specimens when individuals blew into a bag collecting breath that was subsequently passed through a trapping filter [55. THC was removed selectively from the filter and quantified by LC-MS/MS; breath samples from 18 chronic and 11 occasional cannabis users were examined following smoking of a 6.5% THC cigarette [56. THC ≥50 pg/filter was detected up to 4 h after cannabis smoking in frequent cannabis users and for a shorter time in occasional users. Thus, while breath is a good matrix for identifying recent cannabis use, no THCCOOH has been identified in breath [56. Many companies are pursuing the development of cannabis breathalyzers for roadside DUID testing. Of note, it is important not to contaminate breath specimens with oral fluid because cannabis concentrations may be in the thousands of µg/l immediately after intake. Taken together, breath THC represents a promising future matrix for monitoring recent THC intake, provided that manufacturers can develop on-site instruments that are specific and sensitive in identifying low pg/filter THC concentrations.
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