MRK—BACE-inhibitor prodromal phase-3 stopped for futility: https://www.businesswire.com/news/home/20180213006582/en This trial had been scheduled to read out in 2019 (#msg-128708268). The drug in question, Verubecestat, has now failed phase-3 AD trials in both the both mild-to-moderate and prodromol populations.