Innovation Pharmaceuticals Inc (IPIX)

[biodoc]

You've made the argument for Kevetrin continuous intravenous infusion.

Steady state levels are achievable. Dosing is titratable as tolerated. Adverse reactions from rapid IV loading are eliminated.

Long-term intravenous ports (e.g. Port-A-Cath) are a mild inconvenience when confronting late stage cancer. There are a range of pump technologies available with some preferable for home use and others that are more portable.

A couple questions:
(1) Is a continuous infusion of Kevetrin tolerated even at a low dose?
(2) If tolerated, is Kevetrin efficacious in treating p53 impacted cancers?

I think oral Kevetrin is a great idea and it should be reasonably convenient but 3 or more times per day dosing is not that easy. How well do you do taking an antibiotic 3x per day for 14 days? Most do poorly and don't complete the full course.

A 2 hr half life drug with 3x per day dosing will have significant serum peaks and troughs which is not ideal. I agree that frequent oral dosing is appealing but to get to the bottom line if Kevetrin is tolerated and therapeutic, continuous infusion is the way to go.

For those unfamiliar with long-term IV ports, these are not just regular IVs.

Port-a-cath description

I'll get off my soapbox now.

biodoc