I remember that Merck study well. It went on for a long time trying to prove that lowering cholesterol further than other statins reverses plague and survival. They were obviously very disappointed that it didn't show much beyond people with DM. There must be some presumption that HeFH is like some early death sentence but I don't see that in our tree. The early generation presented with blockages/MI in their sixties and some live on till old age 90+, ie the ones I know of. Not unlike the overall population. We have good living habits, no DM that I know of. One that can compete at the national level at his favorite sport.
So back to my original question that is, HeFH folks have good enough options now, at least in my family tree. Where do you see the value added (market) for the new molecules?
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